abstract：:Although calcitonin gene-related peptide (CGRP) has been shown to be elevated in jugular venous blood of adult migraineurs during acute migraine attacks, it remains unknown whether CGRP is increased outside of attacks in jugular or cubital venous blood. The aim of the present study was to compare interictal plasma lev...

journal_title：Pain

authors： Ashina M,Bendtsen L,Jensen R,Schifter S,Olesen J

更新日期：2000-05-01 00:00:00

abstract：:Cognitive factors are thought to play an important mediational role between pain and consequent levels of suffering, yet there has been little investigation of these issues in older chronic pain patients. The present study sought to examine the reliability and validity of the Pain Locus of Control (PLOC) scale when us...

journal_title：Pain

authors： Gibson SJ,Helme RD

更新日期：2000-04-01 00:00:00

abstract：:The aim of this paper is to study the synergistic anti-analgesic effect of angiotensin II (Ang II) plus cholecystokinin octapeptide (CCK-8). Our previous studies have shown that both CCK-8 and Ang II are potent anti-opioid substances. Intracerebroventricular (i.c.v.) injection of CCK-8 or Ang II dose-dependently antag...

journal_title：Pain

authors： Han NL,Luo F,Bian ZP,Han JS

更新日期：2000-04-01 00:00:00

abstract：:The aim of this study was to investigate the effect of injection of serotonin (5-HT) into the masseter muscle on pain and allodynia/hyperalgesia. Twelve female patients with fibromyalgia (FM) and 12 age-matched female healthy individuals (HI) participated in the study. The current pain intensity (CPI) and the pressure...

journal_title：Pain

authors： Ernberg M,Lundeberg T,Kopp S

更新日期：2000-03-01 00:00:00

abstract：:Physical and psychosocial disability in patients with chronic pain have been shown to be associated with patients' pain-related beliefs, tendency to catastrophize, and pain coping strategy use. However, little is known about whether beliefs, catastrophizing, and coping strategies are independently associated with pati...

journal_title：Pain

authors： Turner JA,Jensen MP,Romano JM

更新日期：2000-03-01 00:00:00

abstract：:Ten healthy subjects (four male) of mean age 31 years (range 25-40) took part in a randomized double-blind four-way crossover study to examine the cognitive and psychomotor effects of repeated oral doses of dextropropoxyphene and morphine. Four treatments were compared: dextropropoxyphene napsylate 100 mg, morphine su...

journal_title：Pain

authors： O'Neill WM,Hanks GW,Simpson P,Fallon MT,Jenkins E,Wesnes K

更新日期：2000-03-01 00:00:00

abstract：:Spasticity is a major clinical manifestation of spinal cord injury and upper motor neuron syndrome. ...

journal_title：Pain

authors： Ridgeway B,Wallace M,Gerayli A

更新日期：2000-03-01 00:00:00

abstract：:Dynorphin A is an endogenous opioid peptide, which has previously been shown to produce a long-lasting allodynia and hyperalgesia in mice, behavioral states consistent with signs of clinically observed neuropathic pain. This dynorphin-induced allodynia was used as a pharmacological, central model of neuropathic pain. ...

journal_title：Pain

authors： Laughlin TM,Bethea JR,Yezierski RP,Wilcox GL

更新日期：2000-02-01 00:00:00

abstract：:Injured afferent neurons produce spontaneous activity that is generated away from the normal impulse generation site. Since this activity, referred to as ectopic discharges, may play a significant role in neuropathic pain, it is important to systematically analyze the activity in various pain states. The present study...

journal_title：Pain

authors： Han HC,Lee DH,Chung JM

更新日期：2000-02-01 00:00:00

abstract：:Cognitions and beliefs appear important in predicting adjustment to chronic pain. The current study examines how cognitions and beliefs are related to psychosocial functioning. One hundred and sixty-three chronic pain out-patients were assessed. Regression analyses were performed using scores on the Pain Beliefs and P...

journal_title：Pain

authors： Stroud MW,Thorn BE,Jensen MP,Boothby JL

更新日期：2000-02-01 00:00:00

abstract：:We report the case of bilateral hand swelling following acupuncture therapy for chronic low back pain. Despite thorough history, examination and laboratory testing no systemic cause for the swelling could be elicited. This case highlights the incomplete knowledge of acupuncture mechanisms and that limited acupuncture ...

journal_title：Pain

authors： McCartney CJ,Herriot R,Chambers WA

更新日期：2000-02-01 00:00:00

abstract：:Interactions between the input from cutaneous and nociceptive muscle afferents in polysynaptic reflex pathways were investigated in man. Interaction was tested by evoking reflexes before, during, and after a period of muscle pain induced by intramuscular injection of hypertonic saline. Muscle pain was induced either i...

journal_title：Pain

authors： Andersen OK,Graven-Nielsen T,Matre D,Arendt-Nielsen L,Schomburg ED

更新日期：2000-01-01 00:00:00

abstract：:The present study investigated the role of micro, delta, and kappa receptors within the RVM in mediating expression of conditional hypoalgesia (CHA). Five groups of rats with RVM cannulae were given daily sessions of paired or unpaired presentations of an auditory CS (white noise) and foot shock across three consecuti...

journal_title：Pain

authors： Foo H,Helmstetter FJ

更新日期：1999-12-01 00:00:00

abstract：:The N-methyl-D-aspartic acid (NMDA) receptor antagonist D, L-2-amino-5-phosphonopentanoic acid (AP5) caused a stronger inhibition of wind-up in single wide dynamic range (WDR) neurons after carrageenan inflammation compared with control neurons without inflammation in the receptive field. This indicates that even a sh...

journal_title：Pain

authors： Svendsen F,Rygh LJ,Hole K,Tjølsen A

更新日期：1999-12-01 00:00:00

abstract：:This experiment had three goals: 1. To identify the basis of sucking-induced analgesia in healthy, term, newborn humans undergoing the painful, routine, procedure of heel lance and blood collection. 2. To evaluate how taste-induced and sucking-induced analgesias combine to combat pain. 3. To determine whether facial g...

journal_title：Pain

authors： Blass EM,Watt LB

更新日期：1999-12-01 00:00:00

abstract：:The primary purpose of this study was to examine the extent to which specific patient attitudes and beliefs about medical care and self-care for back pain predict future healthcare use. An automated database allowed examination of the predictive relationships in two primary care patient samples. In general, beliefs th...

journal_title：Pain

authors： Saunders KW,Von Korff M,Pruitt SD,Moore JE

更新日期：1999-11-01 00:00:00

abstract：:Sciatica is a common pain problem and current pharmacologic therapies have proven inadequate for many patients. The objective of this sham-controlled investigation was to compare a novel non-pharmacologic technique, percutaneous electrical nerve stimulation (PENS), to transcutaneous electrical nerve stimulation (TENS)...

journal_title：Pain

authors： Ghoname EA,White PF,Ahmed HE,Hamza MA,Craig WF,Noe CE

更新日期：1999-11-01 00:00:00

abstract：:Anecdotal reports suggest that the general anaesthetic drug ketamine, taken orally in low doses, can give rise to some extra analgesia in patients with refractory neuropathic pain. This study was designed to determine the proportion of patients with chronic neuropathic pain responding to oral ketamine, and then to sep...

journal_title：Pain

authors： Haines DR,Gaines SP

更新日期：1999-11-01 00:00:00

abstract：:In preparation for a series of electrophysiological experiments in a model of neuropathic pain, the present spinal reflex study was done to determine the optimal time after sciatic nerve constriction in the rat for tactile allodynia and to determine also the appropriate 'control' for the nerve constriction model. Ther...

journal_title：Pain

authors： Pitcher GM,Ritchie J,Henry JL

更新日期：1999-10-01 00:00:00

abstract：:The present paper presents the relationship between the total body-pain (TBP) score, defined as the total number of areas shaded on a pain drawing, and the pain from one area, the Shoulder-Neck (SN), among subjects in or out of full-time gainful work respectively. Furthermore, relationships between pain-score, self-ex...

journal_title：Pain

authors： Ektor-Andersen J,Isacsson SO,Lindgren A,Ørbæk P,Malmö Shoulder-Neck Study group.

更新日期：1999-09-01 00:00:00

abstract：:Amitriptyline, a non-selective noradrenaline (NA) and 5-hydroxytryptamine (5-HT) reuptake inhibitor, has recently been demonstrated to produce a peripheral antinociceptive action in an inflammatory (formalin test) and a neuropathic pain model (spinal nerve ligation). In the present study, we determined whether desipra...

journal_title：Pain

authors： Sawynok J,Esser MJ,Reid AR

更新日期：1999-08-01 00:00:00

abstract：:The cell soma of primary afferent neurons in the dorsal root ganglion (DRG) is assigned by classical neurophysiology the role of a metabolic depot, charged with supporting the peripheral sensory ending, the conducting axon, and the central synaptic terminals. However, certain peculiarities of DRG morphology and physio...

journal_title：Pain

authors： Devor M

更新日期：1999-08-01 00:00:00

abstract：:The gate control theory's most important contribution to understanding pain was its emphasis on central neural mechanisms. The theory forced the medical and biological sciences to accept the brain as an active system that filters, selects and modulates inputs. The dorsal horns, too, were not merely passive transmissio...

journal_title：Pain

authors： Melzack R

更新日期：1999-08-01 00:00:00

abstract：:Injection of a dilute solution of formalin into a rat hindpaw produces a biphasic nociceptive response consisting of an early phase during the first 5 min after formalin injection and a later phase starting after 15 min and lasting for 40-50 min. The period between the two phases of nociceptive responding is generally...

journal_title：Pain

authors： Henry JL,Yashpal K,Pitcher GM,Coderre TJ

更新日期：1999-07-01 00:00:00

abstract：:The purpose of this article is to review the sixteen published studies that examine associations between the perception of experimentally induced pain across menstrual cycle phases of healthy females. We also performed a meta-analysis to quantitatively analyze the data and attempt to draw conclusions. The results sugg...

journal_title：Pain

authors： Riley JL 3rd,Robinson ME,Wise EA,Price D

更新日期：1999-06-01 00:00:00

abstract：:Although it is well known that cannabinoids produce antinociception in acute pain models, there is less information on the ability of cannabinoids to alleviate hyperalgesia. In the present study, we determined whether cannabinoids attenuated the development of hyperalgesia produced by intraplantar injection of capsaic...

journal_title：Pain

authors： Li J,Daughters RS,Bullis C,Bengiamin R,Stucky MW,Brennan J,Simone DA

更新日期：1999-05-01 00:00:00

abstract：:Few surveys have been performed to define the characteristics and impact of breakthrough pain in the cancer population. In this cross-sectional survey of inpatients with cancer, patients responded to a structured interview (the Breakthrough Pain Questionnaire) designed to characterize breakthrough pain, and also compl...

journal_title：Pain

authors： Portenoy RK,Payne D,Jacobsen P

更新日期：1999-05-01 00:00:00

abstract：:We report findings from clinical examination and cutaneous laser stimulation in a 57-year-old male, who suffered from a right-sided postcentral stroke. In this patient, we were able to demonstrate (i) a dissociation of discriminative and affective components of pain perception and, for the first time in humans, (ii) t...

journal_title：Pain

authors： Ploner M,Freund HJ,Schnitzler A

更新日期：1999-05-01 00:00:00

abstract：:To clarify the relationships between physical, and psychosocial components of chronic pain, a path analytic model was tested conceptualizing self efficacy as a mediator of disability. In turn, disability was hypothesized to mediate depression. This model could help explain the circumstances under which disability deve...

journal_title：Pain

authors： Arnstein P,Caudill M,Mandle CL,Norris A,Beasley R

更新日期：1999-04-01 00:00:00

abstract：:This study focuses on changes in adrenergic sensitivity in untransected sensory axons that innervate an area of skin made neuropathic by transection of neighboring nerves. The segmental nerve injury model is favorable for this since all axons in the L5 and L6 nerves are transected whereas the L4 axons are intact. Earl...

journal_title：Pain

authors： Moon DE,Lee DH,Han HC,Xie J,Coggeshall RE,Chung JM

更新日期：1999-04-01 00:00:00

abstract：:Clinical pain syndromes, and experimental assays of nociception, are differentially affected by manipulations such as drug administration and exposure to environmental stress. This suggests that there are different 'types' of pain. We exploited genetic differences among inbred strains of mice in an attempt to define t...

journal_title：Pain

authors： Mogil JS,Wilson SG,Bon K,Lee SE,Chung K,Raber P,Pieper JO,Hain HS,Belknap JK,Hubert L,Elmer GI,Chung JM,Devor M

更新日期：1999-03-01 00:00:00

abstract：:Age and sex differences were investigated in children's self-report of venipuncture pain. Equal numbers of boys and girls aged 3-15 years (n = 110) made separate ratings of the intensity and unpleasantness of their needle pain, using a paired Visual Analogue Scale (VAS) technique. The parents of these children used th...

journal_title：Pain

authors： Goodenough B,Thomas W,Champion GD,Perrott D,Taplin JE,von Baeyer CL,Ziegler JB

更新日期：1999-03-01 00:00:00

abstract：:P2X3 purinoceptor cellular distribution was studied in rat sensory neurons in naive animals and following peripheral nerve injury using immunohistochemical methods. Specific antiserum was raised in rabbits and characterized by Western blot, absorption assays and labeling of recombinant receptors. In naive animals, P2X...

journal_title：Pain

authors： Novakovic SD,Kassotakis LC,Oglesby IB,Smith JA,Eglen RM,Ford AP,Hunter JC

更新日期：1999-03-01 00:00:00

abstract：:The main goal of current pain management approaches is to increase the patients' quality of life by improving pain coping skills and by reducing the levels of disability in daily life, often despite persistent pain. Direct measurement of quality of life is of crucial importance in economic evaluation research, in whic...

journal_title：Pain

authors： Goossens ME,Vlaeyen JW,Rutten-van Mölken MP,van der Linden SM

更新日期：1999-03-01 00:00:00

abstract：:Chronic severe cervico-facial pain syndrome associated with a whiplash-type injury was successfully treated with epidural spinal cord stimulation. The patient had been in pain for 9 years, responding temporarily only to stellate ganglion blocks. The patient has now been painless for 18 months. We have been unable to f...

journal_title：Pain

authors： Kirvelä OA,Kotilainen E

更新日期：1999-03-01 00:00:00

abstract：:The L5 spinal nerve ligation model of neuropathic pain in rats has been proposed as a model for sympathetically maintained pain (SMP) based on the effects of surgical or chemical sympathectomy on nerve injury induced behavior. In an attempt to confirm that the lesion produces an animal model of SMP, surgical sympathec...

journal_title：Pain

authors： Ringkamp M,Eschenfelder S,Grethel EJ,Häbler HJ,Meyer RA,Jänig W,Raja SN

更新日期：1999-02-01 00:00:00

abstract：:Substance P (SP) plays a central role in the transduction of second messenger signals from primary afferent nociceptive terminals to second-order neurons in the spinal cord. We have tested a recombinant engineered diphtheria toxin/SP fusion protein (DAB389SP) in acute and chronic pain models in the rat. DAB389SP binds...

journal_title：Pain

authors： Benoliel R,Eliav E,Mannes AJ,Caudle RM,Leeman S,Iadarola MJ

更新日期：1999-02-01 00:00:00

abstract：:Epidural and intrathecal techniques are well established techniques in cancer pain. However, several questions remain unresolved. The several problems of long-term spinal opioid treatment in advance cancer patients were reviewed. Indications for the use of spinal opioids include patients treated by systemic opioids wi...

journal_title：Pain

authors： Mercadante S

更新日期：1999-01-01 00:00:00

abstract：:The clinical effectiveness of locally administered opioids is still under discussion; in particular, the potency of morphine in settings other than intra-articular arthroscopy has been questioned. We developed another pain model, postpartum resection of the fallopian tubes for sterilisation, in which each patient serv...

journal_title：Pain

authors： Rorarius M,Suominen P,Baer G,Pajunen P,Tuimala R,Laippala P

更新日期：1999-01-01 00:00:00

abstract：:Using the indirect immunofluorescence method, the distribution of cyclic GMP (cGMP) and nitric oxide synthase (NOS) was investigated in lumbar 5 dorsal root ganglia (DRGs) of untreated rats 1, 3 and 7 days following sciatic nerve section (axotomy). Untreated and axotomized (7 days) rats were also studied after perfusi...

journal_title：Pain

authors： Sten Shi TJ,Holmberg K,Xu ZD,Steinbusch H,de Vente J,Hökfelt T

更新日期：1998-12-01 00:00:00